Formulation and optimization of porous osmotic pump tablets. Conclusion a porous osmotic pumpbased drug delivery system can be designed for controlled release of highly watersoluble drug oxybutynin. Classify them and write a note on controlled porosity pumps. When these systems are exposed to water, low levels of water soluble additive is leached from polymeric material i. Poorly watersoluble drug with phdependent solubility such as gliclazide glz offers challenges in the controlledrelease formulation because of low dissolution rate and poor bioavailability. Osmotic pumps are most promising for controlled drug delivery, thus can be used for both oral and implantation. Electrolyte management for effective longterm electro. Received 25 aug 20 accepted 10 sept 20 available online sept 20 as dose, absorption rate constant, elimination rate constant, metabolic properties. Recent advances include various specific types of osmotic pump systems such as controlled porosity osmotic pump 20 cpop, osmotic bursting osmotic pump 21 obop, liquid orosliquid oral osmotic system 22 e.
Chinmaya ks, nalini ks, surepalli rmr, muvvala s, kokkula s. Design and development of controlled porosity osmotic tablets. A at least one active agent surrounded by b a rate controlling water insoluble wall, having a fluid permeability of 6. A novel approach in the assessment of polymeric film. The matrix tablets mt were prepared by direct compression method. Osmotic pressure is used as driving force for these systems to release drug in controlled manner. Discuss controlled porosity osmotic pump 06 b write a note on evaluation of osmotic drug delivery systems 05 c discuss various methods for preparation of nanosuspensions 05 q.
To develop swellable controlled porosity osmotic pump tablet of theophylline and to define the formulation and process variables responsible for drug. Review on controlled porosity osmotic pump tablets and its. It was prepared by incorporating drugs in the core and coated with various types. The porous osmotic pump tablets cpop were designed using doptimal design. The electroosmotic conductivity, k eo,is calculated using where q eo is the electroosmotic flux, l is the length of the core, and e is the voltage drop. Apr 14, 2003 a controlled porosity osmotic pump based drug delivery system has been described in this study. Captopril, osmotic tablets, controlled release design and development of controlled porosity osmotic tablets of captopril article history. The pump consists of an osmotic core containing the drug, surrounded by a semipermeable membrane with a delivery orifice. A controlled porosity osmotic pump comprising a tablet coated with ethyl cellulose as a semipermeable membrane containing different levels of channeling agent has been developed for ketorolac tromethamine. Vavia et al 19 studied a controlled porosity osmotic pump based drug delivery system.
One application of this is removing liquid flooding water from channels and gas diffusion layers and direct hydration of the proton exchange membrane in the membrane electrode assembly mea of the proton exchange membrane fuel cells. In the formulation the peaks present due to sodium chloride were 1779. Controlled porosity osmotic pump tablets thesis writing. A a core which comprises a therapeutically effective amount of diltiazem lmalate and an effective buffering amount of sodium bitartrate surrounded by b a rate controlling water insoluble wall, having a fluid. The instant invention is directed to a multiparticulate osmotic pump, for the controlled release of a pharmaceutically active agent to an environment of use, said pump comprising. July september 9 the unique feature of semipermeable membrane utilized for an osmotic pump is that it permits. Controlled porosity osmotic tablet of carvedilol phosphate prepared and evaluated in this study. Formulation and evaluation of osmotic pump delivery of oxybutynin. Osmotic pump, ropinirole, controlled release, factorial design, doptimal design, pptimization. Abstractbackground the osmotic drug delivery systems suitable for oral administration. There is achance of dose dumping if the coating process is not well controlled. A modified twolayered, pushpull osmotic system was developed by using the basic designs of various oral osmotic pumps, such as controlled porosity osmotic pump cpop, elementary osmotic pump eop and pushpull osmotic pump. Rose and nelson developed an implantable pump in 1955. The present study aimed to prepare, optimize, and evaluate tapentadol hydrochloride controlled porosity osmotic pump cpop and to achieve the drug release at nearly zeroorder.
The porous osmotic pump tablets of ropinirole can provide prolonged, controlled and gi environmentindependent drug release. Preparation of controlled porosity osmotic pump tablets for. Development of controlled porosity osmotic pump of metoprolol. In the optimized formulation containing sodium chloride of osmotic pump ls4 peak at 3669. Osmoticpressurecontrolled concentration of colloidal. Design and formulation of nanoporous controlled porosity. Weitz1 colloidal crystals are promising structures for photonic applications. The first of these was the cpop, which was designed to decrease the risk. Osmotic pump with non expanding second chamber specific types. In this book the importance of porous osmotic pump tablets over the matrix tablets for controlled delivery of diclofenac sodium ds were elucidated. Research article formulation of controlled porosity osmotic. The instant invention is directed to an osmotic pump comprising.
Enhancement of dissolution of glipizide from controlled porosity osmotic pump using a wicking agent and a solubilizing agent mahalaxmi. Received 25 aug 20 accepted 10 sept 20 available online sept 20 as dose, absorption rate constant, elimination rate constant, metabolic properties, for correspondence. Formulation and evaluation of controlled porosity osmotic pump for. Design and development of controlled porosity osmotic tablet of.
Formulation and evaluation of losartan potassium osmotic. The cpop was prepared by the coating of polymers eudragit rspo and rlpo on a directly compressed core tablet. Although controlled porosity osmotic pump tablet could be prepared simply, they were usually applicable for soluble drugs. Optimization and development of swellable controlled porosity. For both cells, a 050 v hewlettpackard 6633b power supply was employed in dc constant voltage mode for electroosmotic transport experiments. Osmotically controlled oral drug delivery systems utilize osmotic pressure as energy source for the controlled delivery of drugs, independent of ph and hydrodynamic conditions of gastro intestinal tract git. Formulation aspects in development of controlled porosity. Lornoxicam release from controlled porosity osmotic pump was directly proportional to the pore former sorbitol and level of osmogen mannitol. Pdf a novel controlled porosity osmotic pump system for. Rosenelson pump rose and nelson, the australian scientists, were initiators of osmotic drug delivery. Development and evaluation of a oncedaily controlled. Request pdf recent patent in controlled porosity osmotic pump the porous osmotic pump based drug delivery system for excellent controlled release of. Development and evaluation of controlled porosity osmotic. The desired release profile was obtained by optimizing polymer concentration, channeling agent level, and plasticizer concentration.
When this pump is exposed to water, the core imbibes water osmotically at a controlled rate, determined by the membrane permeability to water and by the osmotic pressure of the core formulation. In this paper, various types of osmotically controlled drug delivery systems and the basic components of controlled porosity osmotic pump tablets have been. Then, controlled porosity osmotic pump cpop tablet of gliclazide was designed to deliver drug in a controlled manner up to 16 h. In cpop water soluble additives dissolve after coming in contact with water, resulting in an in situ formation of a microporous membrane. The controlledporosity osmotic pump has been developed via incorporation of leachable watersoluble small molecules, such as sodium chloride, potassium chloride, urea, and sucrose etc. A controlled porosity osmotic pump cpop delivery system for sodium ferulate was prepared with cellulose acetate ca as semipermeable membrane, polyethyleneglycol 400 peg 400 as channeling. Nov 06, 1990 the instant invention is directed to an osmotic pump comprising. Intensive research has been carried out on osmotic systems and several patents are also published. Apr 29, 2012 a modified twolayered, pushpull osmotic system was developed by using the basic designs of various oral osmotic pumps, such as controlled porosity osmotic pump cpop, elementary osmotic pump eop and pushpull osmotic pump ppop. This device is known as swellable controlled porosity osmotic pump scpop.
Cpop tablets comprise of a core including the drug, an osmotic agent, other additives and semi permeable membrane spm with porogen. It is evident from the results that the rate oxybutynin. A novel controlled porosity osmotic pump system for sodium ferulate article pdf available in pharmazie 6112. Conventional drug delivery systems have slight control over their. Controlled porosity solubility modulated osmotic pump. Elementary osmotic pump delivers 6080% of its contents at a constant rate, and there is a short lag time of 3060 min as the system hydrates before zero order delivery from the elementary osmotic pump is obtained. Osmotic pump tablets offer highly predictable and programmable delivery of drugs into solution, ready for absorption. A what is osmotic pressure osmotic pressure is a most important colligative property according to pharma point of view. Jul 25, 1989 the instant invention is directed to a multiparticulate osmotic pump, for the controlled release of a pharmaceutically active agent to an environment of use, said pump comprising. The coating of semi permeable membrane is done by a suitable coating method. Formulation and optimization of controlled porosity osmotic pump tablet for oral administration of glipizide. Formulation and evaluation of controlled porosity osmotic. Pdf formulation and optimization of controlled porosity osmotic. Osmotic drug delivery using swellablecore technology.
The present study is to develop controlled porosity osmotic pump cpop tablets of stavudine. An electroosmotic pump eop, or eo pump, is used for generating flow or pressure by use of an electric field. Design and formulation of nanoporous controlled porosity osmotic pumps cpops containing a poorly water soluble drug, glibenclamide leila azharshekoufeh b1, yousef javadzadeh1,2, mohammad barzegar jalali3, ali nokhodchi4 and javad shokri1 1drug applied research centre and faculty of pharmacy, tabriz university of medical sciences, tabriz, iran. A system that can deliver drug at a controlled rate is very important for the treatment of various chronic diseases such as diabetes, asthma, and heart disease. Some of the investigators have also studied the role of parameters like coating, release retardants etc. Microporous membranecoated bilayered osmotic tablets of diltiazem hcl were prepared by conventional wet granulation technology. Asian journal of research in chemistry and pharmaceutical. It can ideally suit for a drug of short biological halflife 26h, high potency and needed for chronic.
This system utilizes the principle of osmosis as the prime mechanism, for the delivery of a wide variety of soluble and insoluble drugs 5. The developed formulation was optimized for type and level of pore former and coating weight gain. Enhancement of dissolution of glipizide from controlled. Unlike the elementary osmotic pump eop which consists of an osmotic core with the drug surrounded by a semipermeable membrane drilled with a delivery orifice, controlled porosity of the membrane is accomplished by the use of different channeling.
However, the drawback of this potentially useful hypoglycemic agent is that it is highly hydrophobic and practically insoluble in water. Development of controlled porosity osmotic pump of. The present study was aimed to develop osmotic controlled extended release formulations of losartan potassium an angiotensin. Matrix and porous osmotic pump tablets a comparative. Formulation and evaluation of osmotic pump delivery of. Research article formulation of controlled porosity. Drug release from the developed formulations was independent of ph and agitational intensity and was dependent on. Request pdf recent patent in controlled porosity osmotic pump the porous osmotic pump based drug delivery system for excellent controlled release of drug for 24 hrs. In this paper, we pioneered application of ann for the optimization of the formulation composition of the controlled porosity osmotic pump tablet 7, a practice and learning that may potentially be of benefit to the industry. A boxbehnken experimental design was applied to optimize the parameters for cpop. L oros hard cap, l oros soft cap and delayed liquid bolus delivery system, telescopic capsule, 23 oros ct, 24 sandwiched osmotic. Preformulation, formulation and pharmacokinetic studies, ph.
The developed formulation was optimized for type and level of. Therefore, there was a need to modulate the solubility of the drug using suitable. The design and formulation of an osmotic pump tablet determines the release rate of the drug and are based on exhaustive and expensive physicochemical testing of the systems characteristics. Film coating is a complex and multistep process involving the application of thin polymerbased layers to a substrate under conditions that permit parallel computations between the addition rate of the coating liquid and drying, uniformity. The controlled porosity osmotic pump has been developed via incorporation of leachable watersoluble small molecules, such as sodium chloride, potassium chloride, urea, and sucrose etc. Formulation and optimization of controlled porosity. Optimization and development of swellable controlled. Controlled porosity solubility modulated osmotic pump tablets. Study of drug release from an elementary osmotic pump. The study involves the use of taguchi orthogonal array. Recent patent in controlled porosity osmotic pump request pdf. Formulation and evaluation of oral controlled release osmotic.
Controlled porosity osmotic pump cpopan advanced delivery. Controlled porosity osmotic pump tablet cpop system was designed to deliver nifedipine np and metoprolol mp in a controlled manner up to 12 h. Controlled porosity osmotic pump cpop contains drug, osmogens, excipients in core and a coating of semipermeable membrane with water soluble additives. Drug release from the developed formulations was independent of ph and agitational intensity and was dependent on osmotic pressure of the release media. Formulation and optimization of porous osmotic pump. Granules of the osmogen layer and drug layer that were equivalent to 2000 tablets were prepared with pvp k30m as a binder. Describe the evaluation tests for suitability of glass. This article is from journal of basic and clinical pharmacy, volume 4. Dec 17, 2015 the present study aimed to prepare, optimize, and evaluate tapentadol hydrochloride controlled porosity osmotic pump cpop and to achieve the drug release at nearly zeroorder. Liquid oros a l oros hard cap b l oros soft cap c delayed liquid bolus delivery system. Studied a controlled porosity osmotic pumpbased drug delivery system. R1, phanidhar sastri1, ravikumar3, atin kalra1, pritam kanagale. Asian journal of research in chemistry and pharmaceutical sciences.
The aim of the current study was to design a controlled porosity osmotic pump cpopbased drug delivery system for controlled release of an nsaid agent. Controlled porosity osmotic pump cpop were introduced, the cpop consists of a an osmotic core that contains the drug and along with an osmogent and b a semipermeable membrane coating that contains a watersoluble poreforming agent, instead of the delivery orifice created by laser drill3. The comparative study of elementary osmotic pump eop and controlled porosity osmotic pump revealed that it superior than conventional eop and also easier. Controlled porosity osmotic pump cpop controlled porosity osmotic pump is an osmotic tablet in which membrane contains water soluble leachable pore forming agents. Osmotic drug delivery technique is the most interesting and widely acceptable among all other technologies used for the same. Brad hanson, evaluation of a phosphoryloxymethyl pom prodrug of camptothecin. A system that can deliver multidrug at a prolonged rate is very important for the treatment of various chronic diseases such as diabetes, asthma and heart disease. Formulation and evaluation of oral controlled release.
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